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USMLE Step 1 Review Course

USMLE Step 1 Course Based on First Aid 2019 Edition

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USMLE Step 1 Membership Plans


  • Step 1 Review course over 250 hours of USMLE lectures
  • USMLE Question Bank 2300 + Practice USMLE Questions
  • USMLE Flash Cards
  • Video Lecture Progress monitor your video views
  • Complete Platform Access Mobile, smartphones, desktop
  • USMLE Study Guide Free USMLE step 1 prep book
  • Free Audio Book Guide Prep guide audibook with online calendar
  • Phone consultation with MD personal consultation (value $200)
  • Personalized USMLE schedule Get your schedule reviewed by MD
  • Personal USMLE Advisor Anytime access to personal advisor
Features »
Course features
1 month

$33/ day

  • Step 1 Review course  
    over 250 hours of USMLE lectures
  • USMLE Question Bank  
    2300 + Practice USMLE Questions
  • USMLE Flash Cards  
    USMLE Flash Cards
  • Video Lecture Progress  
    monitor your video views
  • Complete Platform Access  
    Mobile, smartphones, desktop
  • USMLE Study Guide  
    Free USMLE step 1 prep book
  • Free Audio Book Guide  
    Prep guide audibook
  • Phone consultation with MD  
  • Personalized USMLE schedule  
  • Personal USMLE Advisor  
6 months

$11/ day

Most popular
  • Step 1 Review course  
    over 250 hours of USMLE lecture
  • USMLE Question Bank  
    2300 + Practice USMLE Questions
  • USMLE Flash Cards  
    USMLE Flash Cards
  • Video Lecture Progress  
    monitor your video views
  • Complete Platform Access  
    Mobile, smartphones, desktop
  • USMLE Study Guide  
    Free USMLE step 1 prep book
  • Free Audio Book Guide  
    Prep guide audibook
  • Phone consultation with MD  
    Free 1 hr phone consultation
  • Personalized USMLE schedule  
  • Personal USMLE Advisor  
3 months

$14/ day

  • Step 1 Review course  
    over 250 hours of USMLE lectures
  • USMLE Question Bank  
    2300 + Practice USMLE Questions
  • USMLE Flash Cards  
    USMLE Flash Cards
  • Video Lecture Progress  
    Video lecture Progress
  • Complete Platform Access  
    Mobile, smartphones, desktop
  • USMLE Study Guide  
    Free USMLE step 1 study guide
  • Free Audio Book Guide  
    free audiobook Prep guide
  • Phone consultation with MD  
  • Personalized USMLE schedule  
  • Personal USMLE Advisor  
12 months

$6/ day

  • Step 1 Review course  
    over 250 hours of USMLE lectures
  • USMLE Question Bank  
    2300 + Practice USMLE Questions
  • USMLE Flash Cards  
    USMLE Flash Cards
  • Video Lecture Progress  
    Video lecture Progress
  • Complete Platform Access  
    Mobile, smartphones, desktop
  • USMLE Study Guide  
    Free USMLE step 1 study guide
  • Free Audio Book Guide  
    free audiobook Prep guide
  • Phone consultation with MD  
    Free 2 hr phone consultation
  • Personalized USMLE schedule  
    Get your schedule reviewed by MD
  • Personal USMLE Advisor  
    Schedule an appointment with MD anytime


USMLE Step 1 Qbank  Plans

1 Month

30 days

  • STEP 1 Qbank 2200 Step 1 questions
3 Months

90 days

  • STEP 1 Qbank 2200 Step 1 questions
6 Months

180 days

Most Popular
  • STEP 1 Qbank 2200 Step 1 questions
12 Months

365 days

  • STEP 1 Qbank 2200 Step 1 questions

SmashUsmle Prep program is the leading USMLE step 1 review company that has helped thousands of medical students prepare and ace the USMLE step 1 through our USMLE step 1 review course.

What do we offer?

- 250 hours of high yield USMLE step 1 review video lectures

- Free 2000 + USMLE step 1 question bank written by our USMLE physician experts

    o Test Mode simulates the real USMLE exam, and Tutor Mode answer questions with immediate detailed explanations during USMLE step 1     review study sessions.

    o Rich media questions with charts, illustrations to help you master the information.

    o Free performance analytics tracker for question bank

- Free 800 high yield USMLE flashcards

- Free USMLE advisor tutorial on how to smash the USMLE exam

- Free USMLE prep Ebook

- Free audiobook to prepare for the USMLE

- Free Downloadable pdf summary of each USMLE video lecture

- Fast forward option using 1.5x, 2.0x to increase video speed

- Free Live online calendar to monitor your board schedule

- Free access to our physician experts to answer your questions

- Free daily motivational quotes to enhance your study

- Access all content on all platforms- mobile, tablets, desktops.

What makes us different from other competitors?

No power point presentations. All USMLE video lectures are taught on a whiteboard with hand drawn diagrams to explain all high yield content relevant to the USMLE

We cover all topics in First Aid for the USMLE but explain in details how you should understand the concepts and tell you how the concepts will be tested on the USMLE.

Basic Sciences

Cells of immune system

Lymphoid structures

Lymphatic drainage

Secondary Lymphoid structures- The Spleen and Lymph nodes

Innate vs adaptive immunity

MHC class I and II

HLA and disease associations

T cell activation and immunity

B cells-antibodies and humoral immunity

interleukins overview

Active vs passive immunity


Hypersensitivity response

Blood transfusion reactions

T cell disorders

B cells immunodeficiency disorders

B and T cell disorders

Transplant rejection and Grafts





Introduction to vitamins

Introduction to metabolism


Lysosomal storage diseases

Respiratory Burst


Pyruvate metabolism


Glycogen synthesis- storage diseases

Fructose metabolism

Citric acid (Kreb) cycle

Electron transport chain

Pyruvate kinase deficiency


Maple syrup urine disease

Urea Cycle

Lactase deficiency



Fatty Acid Synthesis and beta oxidation

Ethanol metabolism

Catecholamine synthesis

Amino acid metabolism






Behavioral Sciences


Types of studies

Clinical Trial

Sensitivity and Specificity

Incidence vs Prevalence.

Quantifying Risk Quantification

Precision vs Accuracy

Bias and Study Errors

Statistical distribution

Statistical hypotheses

Outcomes of Statistical hypothesis testing

Meta Analysis

Confidence interval

Chi square, T-test and analysis of variance

Pearson correlation coefficient (r)

Disease prevention

Medicare and Medicaid


Core ethical principles

Informed consent

Consent for minors

Decision-making capacity

Advance directives

Surrogate decision- maker


Ethical situations



Cell injury and changes

Cell Adaptation



Acute inflammation

Chronic inflammation

Granulomatous inflammation

Wound healing and repair



General principles of pharmacology

What is Pharmacokinetics

Drug Absorption Overview

Drug Bioavailability Overview

Drug Distribution Overview

Drug Distribution Overview

Volume of Distribution

First pass metabolism

Phase 1 metabolism

Phase 2 metabolism

First Order Zero Order Elimination

Drug Half-life An Overview

First Order Elimination Rate Constant and Half-life

Drug Clearance

Renal Excretion of Drugs Pharmacokinetics

Enzyme Induction

Competitive Inhibition Overview

Competitive Inhibition Statins


Autonomic nervous system


Intro to autonomic Nervous system pharmacology

Cholinergic Agonists

Cholinergic Antagonists

Adrenergic Agonists

Adrenergic Antagonists


CNS drugs

Introduction to Antidepressant Drugs

Selective Serotonin Reuptake Inhibitors (SSRIs)

Serotonin Norephinephrine Reuptake Inhibitors (SNRIs)

Tricyclic Antidepressants (TCAs)

Monoamine oxidase inhibitors (MAOis)

Atypical Antidepressants


atypical antipyschotics













Parkinson Drugs


Dopamine agonist- Bromocriptine

COMT inhibtors- Entacapone




Antimuscarinics- benztropine


Cardiovascular drugs

Antihypertensive Drugs

Antiarrhymic Drugs

Congestive heart failure Drugs


Anticoagulants: Heparin

Anticoagulants: Warfarin (Coumadin)

Thrombolytics- tPA (Alteplase)

Glycoprotein IIB/IIIA – Clopidogrel

ADP Inhibitors- Clopidogrel, Ticlopidine

Cilostazol/ Dipyramidole (Persantine)

Lipoprotein Metabolism Physiology

Familial Dyslipidemia

Statins – Lovastatin, simvastatin

Niacin (Nicotinic Acid)

Bile Acid resins- cholestyramine, cholestipol



Respiratory system drugs

Asthma drugs/COPD Drugs



Leukotriene Inhibitors



Cough and Cold Drugs

Musculoskeletal drugs

NSAIDS – Ibuprofen, Ketorolac, Naprosyn


Gout Drugs- Colchicine, Allopurinol, Indomethacin

Gastrointestinal drugs

Peptic Ulcer disease drugs

Crohns and Ulcerative colitis drugs


Antimicrobial drugs



Protein systhesis inhibitors


Folate Antagonists














HIV (HAART) drugs

Introduction to antiprotozoal drugs


Chagas Disease Drugs

Anti-leishmania Drugs



Herpes Viruses











Recombinant cytokines


Bacteria Cell Wall Function

Bactrial Classification Algorithm

Bacteria Morphology

Bacteria Staining Techniques

Microbiology Exotoxins

Bacteria Growth Curve

Bacteria Endotoxin

Aerobes And Anerobes

Gram Positive Bacteria

Yersinia Enterocolitica




Viral Structure And Genetics

RNA Viruses

DNA Viruses


Pseudomonas Aeroginosa


Mycoplasma Pneumoniae


Legionella Pneumophila



Helicobacter Pylori

Haemophilus Influenzae

Gardenerella Vaginalis

Opportunistic Fungal Infections



Campylobacter Jejuni

Bordetella Pertussis

Microbiology High Yield Review



Organ Systems

Acute Appendicitis
Acute Gastritis
Acute Pancreatitis
Acute Mesenteric Ischemia
Carcinoid syndrome
Choledocolithasis/ Ascending Cholangitis
Cholelithiasis- Gallstone Pathology
Chronic Pancreatitis
Diseases of the Esophagus: Achalasia
Diseases of the Esophagus: Diffuse Esophageal Spasm
Diseases of the Esophagus: Esophageal Cancer
Diseases of the Esophagus: Esophagitis
Diseases of the Esophagus: Introduction
Esophageal Diverticula/Zenkers Diverticulum
Gastroesophageal Reflux Disease (GERD)
Gastrointestinal Bleeding
Hepatitis B
Hepatocellular Carcinoma
Inflammatory Bowel Disease: Crohns Disease
Inflammatory Bowel Disease II: Ulcerative colitis
Jaundice – Hyperbilirubinemia
Liver Cirrhosis
Liver Function Test (AST/ALT)
Peptic Ulcer Disease (PUD)
Primary Biliary Cirrhosis
Primary sclerosing Cholangitis
Small Bowel Obstruction
pancreatic adenocarcinoma
Wilson’s Disease
Hereditary hyperbilirubinemia
Reye’s syndrome
Colon cancer
Intestinal disorders
Duodenal atresia
Hirschsprungs disease
intussucception and volvulus
Meckels Diverticulum
Celiac sprue
Pyloric stenosis
Liver anatomy

Reproductive system

Male reproductive anatomy

Spermatogenesis and androgens

Female reproductive cycle


Pregnancy complications

Placenta Previa

Placenta Accreta

Placenta Abruption

Polycystic ovarian syndrome

Sex Chromosomes Disorders

Klinefelters syndrome

Turner’s syndrome
Androgen insensitivity syndrome

5 alpha reductase deficiency

Kallman syndrome

Hydatidiform mole

Ectopic pregnancy


Endometrial pathology

Myometrial tumors

cervical cancer

Ovarian Tumors

Breast Tumors

Benign Prostatic Hyperplasia

Prostate cancer

Testicular disorders


Urinary Tract Infection

Autosomal dominant Polycystic Kidney Disease

Horseshoe Kidney


Renal Cell Carcinoma

Renal Tubular Acidosis (RTA)

Transitional Cell Carcinoma

Wilms tumor


Respiratory Alkalosis

Renin-Angiotensin-Aldosterone system (Blood pressure Regulation)

Nsaids Nephropathy/ Renal Papillary Necrosis

Nephrotic syndrome

Nephritic Syndrome

Chronic Renal Failure Part 2: Uremia Induced bleeding

Chronic Renal Failure Part 1

Acute Tubular Necrosis

Acute Renal Failure

Acute Interstitial Nephritis

Acid-base Disorders: Introduction to the Basics

Acid-Base Disorder: Respiratory Acidosis

Acid-base disorder: Metabolic Alkalosis

Acid-base Disorder: Metabolic Acidosis


Coronary circulation lecture
Heart sounds basics
Congestive heart failure
Deep venous thrombosis (DVT)
Disease of Vasculature: Hypertensive Emergency
Diseases of Vasculature: Abdominal Aortic Aneurysm
Diseases of Vasculature: Abdominal Aortic dissection
EKG lectures tutorial
Introduction to EKG physiology
EKG: Atrial Fibrillation
EKG: Heart Blocks
EKG Tutorials: How to read a Normal EKG
EKG Tutorials: Supraventricular Tachycardia
Introduction to Hypertension
Hypertension Part 2
Infective Endocarditis
Ischemic Heart Disease: Acute Coronary Syndrome
Wolff parkinson white syndrome animation
Complication of Acute Myocardial Infarction
Ischemic Heart Disease: Prinzmetals Angina
Ischemic Heart Disease: Stable Angina
Pericardial Diseases: Acute Pericarditis
Pericardial Diseases: Cardiac Tamponade
Peripheral Vascular Disease: Atherosclerosis
SHOCK: Understanding the Basics of Shock
SHOCK: Cardiogenic Shock
SHOCK: Hypovolemic Shock
SHOCK: Neurogenic Shock
SHOCK: Septic Shock
Valvular Heart Disease: Aortic Stenosis
Valvular Heart Disease: Mitral Regurgitation
Valvular Heart Disease: Mitral Stenosis
Valvular Heart Disease: Tricuspid Regurgitation
Blood pressure Regulation II:: Renin-Angiotensin-Aldosterone system
Blood Pressure Regulation I: Baroreceptor Pathway
Cardiology Arrythmias Animations
Congenital Heart Disease: Atrial Septal Defect (ASD)
Congenital Heart Disease: Ventricular Septal Defect (VSD)



Ego defense mechanisms

Attention deficit hyperactivity disorder (ADHD)

Tourettes syndrome

Oppositional defiant disorders

Pervasive developmental disorder

Separation anxiety disorder

Major depressive disorder

Panic disorder

Manic episodes and bipolar disorders

Transference and countertransference



1. Demyelination Disorders I: Multiple Sclerosis

2. Demyelination Disorders II: Gullian Barre Syndrome

3. Duchenne’s Muscular Dystrophy

4. Epidural & Subdural Hematomas

5. Head Trauma: Intracranial Pressure (ICP)

6. Hemorrhagic Stroke: Intracranial & Subarachnoid Hemorrhage

7. Movement Disorders 1: Basal Ganglia Structure & Function

8. Movement Disorders 2: Parkinsons Disease

9. Movement Disorders 3: Huntington’s Disease

10. Myasthenia Gravis

11. Seizures

12. Stroke Part 1: Circle of Willis Anatomy

13. Stroke Part 2: Cerebrovascular Diseases

14. Stroke Part 3: Cerebrovascular Diseases (Diagnosis & Treatment)

15. Cranial Nerves and clinical application

16. Ventricular system pathology

17. Spinal cord pathways

18. Spinal cord lesions

19. Brain tumors

20. Headaches

21. Glaucoma

22. Dementia and Delirium

23. Neurocutaneous syndromes

Musculoskeletal system

Brachial Plexus

Crystal Induced Arthritides: Gout

Crystal Induced Arthritides: Pseudogout

Inflammatory Bowel Disease: Crohns Disease

Inflammatory Bowel Disease: Ulcerative Colitis

Origins and insertions of upper extremities

Origins and insertions III

Polymyalgia Rheumatica

Polymyositis & Dermatomyositis

Rheumatoid Arthritis (RA)

scleroderma (System Sclerosis)

Seronegative Arthropathy: Ankylosing spondylitis

Seronegative Arthropathy: Psoaritic Arthritis

Seronegative Arthropathy: Reactive Arthritis

Sjogren’s Syndrome

Systemic Lupus Erythematosus


Hematology & Oncology

1. Anemia Part 1: The Red Blood Cell

2. Anemia Part 2: Heme Synthesis

3. Anemia Part 3: Basics to Anemia

4.Anemia Part 4: Microcytic Anemia- Iron Deficiency Anemia

5. Anemia Part 4a: Microcytic Anemia- Sideroblastic Anemia

6.Anemia Part 4b: Microcytic Anemia- Thalassemia

7. Anemia Part 4d: Microcytic Anemia- Anemia of Chronic DIsease

8. Anemia Part 4e: Normocytic anemia- Aplastic Anemia

9. Anemia Part 5: Macrocytic Anemia- Vitamin B12 Deficiency Anemia

10. Anemia Part 5b: Macrocytic Anemia-Folate Deficiency

11. Anemia Part 6: Hemolytic Anemia- Hemolytic Anemia & Hereditary Spherocytosis

12. Anemia Part 7: Hemolytic Anemia- Paroxysmal Nocturnal Hemoglobinuria (PNH)

13. Anemia Part 8: Hemolytic Anemia- G6PD deficiency

14. Anemia Part 9: Hemolytic Anemia- Autoimmune Hemolytic Anemia

15. Anemia Part 9b: Hemolytic Anemia- Sickle Cell disease

16. Coagulation Disorder: Disseminated Intravascular Coagulopathy (DIC)

17. Coagulation Disorder: Hemophilia A & B

18. Coagulation Disorder: Von Willebrands Disease

19. Lymphoma: Hogdkins Disease

20. Lymphoma II: Non-Hogdkins Lymphoma

21. Leukemia II: Chronic Myelogenous Leukemia (CML) & Chronic Lymphocytic leukemia (ALL)

22. Leukemia: Acute Myelogenous Leukemia (AML) & Acute Lymphocytic leukemia (ALL)

23. plasma cell dyscrasia: Multiple Myeloma

24. Platelet Disorder Part 1: Bleeding disorders (platelet Vs Clotting factors disorders)

25. Platelet Disorder Part 2: Thrombocytopenia (Introduction)

26. Platelet Disorder Part 3: Immune Thrombocytopenic Purpura (ITP)

27. Platelet Disorder: Thrombotic Thrombocytopenia Purpura (TTP)

28. The Clotting/Coagulation Cascade

29. Waldenstrom Macroglobulinemia



Adrenal Gland Physiology
Adrenal Insufficiency
Diabetes Insipidus
Diabetes Mellitus (DM)
Diabetic ketoacidosis (DKA)
Diseases of pituitary gland: Acromegaly
Diseases of the Adrenal Gland: Pheochromocytoma
Diseases of the Adrenal Glands: Cushings Syndrome
Diseases of the Parathyroid Glands: Hyperparathyroidism
Diseases of the parathyroid glands: Hypoparathyroidism
Diseases of the thyroid gland: Hyperthyroidism
Diseases of the thyroid gland: Hypothyroidism
Diseases of the thyroid gland: Thyroid Storm
Diseases of the thyroid gland: Thyroiditis
Hyperosmolar Non-ketosis Syndrome (HHNS)
Multiple Endocrine Neoplasia (MEN Syndrome)
Parathyroid Physiology (Calcium Regulation)
Pituitary Gland Physiology: Prolactinoma
Primary Hyperaldosteronism
Syndrome of Inappropriate ADH (SiADH)
Thyroid Gland Pharmacology
Thyroid Gland Physiology
Zollinger Ellison Syndrome/ Gastrinoma
Diabetes: Complications



Acute Respiratory Failure (ARF)
Adult Respiratory Distress Syndrome (ARDS)
Chronic Obstructive Pulmonary Disease (COPD)
Cystic Fibrosis
Diseases of Pulmonary Vasculature: Cor Pulmonale
Diseases of Pulmonary Vasculature: Primary Pulmonary Hypertension
Diseases of Pulmonary Vasculature: Pulmonary Hypertension
Goodpastures Syndrome
Interstitial Lung Disease (ILD)- Introduction
Interstitial Lung Diseases: Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases: Sarcoidosis
Lung Cancer
Pleural Effusions
Pneumoconiosis: Asbestosis
Pneumoconiosis: Berryliosis
Pneumoconiosis: Coal Worker Disease (CWP)
Pneumoconiosis: Silicosis
Pulmonary Embolism (PE)
Respiratory Physiology: Flow-Volume loops

We are one the leading premier company dedicated to providing high yield USMLE step 1 and USMLE step 2 review for medical students and physicians preparing for the board exams.

If you fail the USMLE while using the SmashUSMLE test prep program, you may be eligible to receive a free subscription extension equal in length to your current SmashUSMLE subscription. To be eligible, you must (1) contact us at admin@smashusmle.com, to make the request, (2)have an active, paid subscription of that product within 10 (ten) days of your USMLE test date, (3) provide us a copy of the failing score and the first NBME scheduling permit, and (4) provide us a copy of the second NBME scheduling permit for your next USMLE examination. Once we verify this information, you will receive a subscription extension to the same SmashUSMLE product equal in length to your current SmashUSMLE subscription. You may choose to take this extension in the form of an extension to your existing subscription (thus you will maintain your test histories), or as a new subscription. Limit one extension per paid subscription.  This offer is void if you did not complete the USMLE examination.

MD, DO students and physicians who need take the USMLE/ COMLEX exams.

Yes. If you purchase the USMLE package with question bank, you automatically get access to over 1900 USMLE  step 1 style question to prepare you for the actual exam.

We cover most of the high yield topics tested on the USMLE step 1 and USMLE step 2 exam.

Yes, you get an online free USMLE preparatory guide with audiobook to help guide your preparation for the USMLE exam.

Please contact us at support@smashusmle.com and we will be happy to help you with this issue.

We do not have android, iphone or blackberry app for our website. You can watch our videos through your browser on your android, iphone, blackberry phones. we recommend you use a mac or windows computer to access our site.

You can take the questions as many times as you want and reset the question bank twice.

No. Our videos are not downloadable on any computer systems. You can ONLY watch our lectures solely on our website. This is to protect the privacy of the content of our website.

Yes. You can reset your question bank twice.

Our policies strictly prohibit sharing of subscriptions. If such behaviors is noted on your account, beware that you violate our Terms of Service and we reserve the right to suspend your subscription in response to violations.

Cancellation and refund policy. You may cancel your monthly subscription at any time and for any reason by contacting the Company by sending an email at support@ftplectures.com or admin@smashusmle.com.

Your purchase may qualify for a refund if:
you have not opened/clicked on any of the videos made available to you through your monthly subscription AND requested a refund within the first 14 days following the date of your purchase by sending us an email. Any requests made after the initial 14-day period will not qualify for a refund.
you fail your board exam having completed the entire educational course via your monthly subscription. To qualify for a refund you would need to have completed 100% of the qbank, watched all videos and completed working on all the flashcards. We will offer you a free course or refund you your payment.

All you will need to do is to send us a refund request and submit a written proof of your exam result.
If your purchase does not qualify for a refund and you request to cancel your subscription, you will enjoy the educational materials and videos made available to you through your monthly subscription until the end of that billing cycle.
The Company reserves the right to refuse to issue a refund if the user is found to be in violation of these Terms.

No, Our lectures are not available on CD Rom or DVD formats. This is to avoid piracy of our lecture videos and sharing online on other websites. You can access our videos online from anywhere in the world where there is internet connection. Please, do not request for this service from our company as they are not available

Our questions are always reviewed by clinicians frequently to give you updated content tested on the board exam.

You can pay with a credit card- Visa or MasterCard.

Yes. You can use our videos to prepare for the COMLEX exam. We do not cover OMM at this time, but videos will be made available in the future.

Send your emails to support@smashusmle.com. Call us: (888)-901-9356. Our support hours are 9-5 Eastern, Monday-Friday. If you reach our voice mail, leave a message, a customer representative will contact you as soon possible.

If you subscribe to our “Till you pass*” membership. This is a 12 month subscription to our test prep program. If you use our test prep for 12 months and completed the USMLE exam but failed, you must provide documentation that you failed the test. Email your USMLE transcript to admin@smashsusmle.com. Once we verify this information, we will reactivate your membership. This does not apply if you did not achieve the score you want on the USMLE or did not complete the exam.