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What is the mechanism of action of acetazolamide?
12:00 AM | November 30, -0001Author: Adeleke
carbonic anhydrase inhibitor --> bicarb reabsorption drives the Na/H exchanger in the proximal tubule --> NaHCO3 excreted; causes acidosisContinue reading
Archives
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Na/K/2Cl cotransport inhibitor.
12:00 AM | November 30, -0001Author: Adeleke
Furosemide; acts in ascending limbContinue reading
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This diuretic inhibits NaCl reabsorption in early distal tubule.
12:00 AM | November 30, -0001Author: Adeleke
HydrochlorthiazideContinue reading
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This diuretic is a competitive aldosterone receptor antagonist.
12:00 AM | November 30, -0001Author: Adeleke
Spironolactone, triamteren, amilorideContinue reading
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What is the contraindication of ACE inhibitors?
12:00 AM | November 30, -0001Author: Adeleke
Bilateral renal artery stenosisContinue reading
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Poststreptococcal glomerulonephritis
12:00 AM | November 30, -0001Author: Adeleke
NEPHRITIC- most common type of postinfections GN; usually follows group A strep infection of the skin and pharynx LM: glomeruli enlarged and hypercellurlar, neutrophils, "lumpy bumpy"; EM subepithelial humps; IF granular pattern; ICs activate complement ... Continue reading
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Rapid Progressive (crescentric) glomerulonephritis
12:00 AM | November 30, -0001Author: Adeleke
NEPHRITIC - rapid loss of renal function progresses to acute renal failure; LM and IF; may or may not be associated with crescent formation (# of crescents is what determines prognosis) Associated with goodpastures, microscopic ... Continue reading
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Membranoproliferative glomerulonephritis [diffuse proliferative GN]
12:00 AM | November 30, -0001Author: Adeleke
NEPHRITIC -subendothelial IC deposits with granular IF; EM subendothelial humps "tram tracks"; DNA-anti DNA ICs activate classical complement pathway; common cause of death is SLE, "wire looping"Continue reading
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IgA glomerulonephropathy (Bergers disease)
12:00 AM | November 30, -0001Author: Adeleke
Most common GN almost equal incident of nephritic or neprhotic presentation; Affects children and adults, often post infectious; increased mucosal synthesis and decreased clearance of IgA; increased serum IgA; Mesangial IgA IC deposits within granular. ... Continue reading
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Alport syndrom
12:00 AM | November 30, -0001Author: Adeleke
split basement membrane; collagen IV mutation; nerve deafness and ocular disordersContinue reading