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10. CD8 Tcell differentiation issue
12:00 AM | November 30, -0001Author: Adeleke
ZAP70, TAP 1,2Continue reading
Archives
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11. CD4 Tcell differentiation issue
12:00 AM | November 30, -0001Author: Adeleke
MHCIIContinue reading
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12. ADA SCID deficiency
12:00 AM | November 30, -0001Author: Adeleke
ADA on chromosome 20 defect, reduced DNA synthesis NK, B and T cell problem, undeveloped thymus, rib abnormalities, low WBC, No T-cell response to nonspecific T-cell mitogen phytohemagglutinin, Failure to thrive, bone marrow transplantContinue reading
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13. PNP SCID deficiency
12:00 AM | November 30, -0001Author: Adeleke
NP on chromosome 14 defect, poor B cell activation of T cells, No T cells, B cells not functional, no thymus, Failure to thrive, neuro problems, hemolytic anemia, bone marrow transplantContinue reading
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14. RAG1,2 SCID
12:00 AM | November 30, -0001Author: Adeleke
RAG1,2 on chromosome 11 defect, no T or B cell, sequence gene to diagnose, no thymus, Failure to thrive, bone marrow transplantContinue reading
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15. Omenn syndrome
12:00 AM | November 30, -0001Author: Adeleke
missense mutations in RAG1 of RAG2, T-cell (target self), High IgE, exfoliative dermatitis, Failure to thrive, High IL4 IL5, high eosinophilsContinue reading
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16. Gamma chain X linked SCID
12:00 AM | November 30, -0001Author: Adeleke
IL2RG - γ chain of cytokine receptor for IL-2, IL-4, IL-7, IL-9, IL-15 on X chromosome, No Tcells, no thymus, no Ig, no NK, normal B, Failure to ThriveContinue reading
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18. Wiskott Aldrich Syndrome
12:00 AM | November 30, -0001Author: Adeleke
WAS on X chromosome, involved in T cell signaling, Low B, T and NK, High IgA IgE, Low IgM, increased staphA infections and eczema, petechial rashes, bloody diarrheaContinue reading
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19. Leukocyte adhesion deficiency
12:00 AM | November 30, -0001Author: Adeleke
CD18 defective coreceptor for leukocyte phagocytosis, no puss, neutrophilia, delayed detachment of the umbilical cordContinue reading