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Steps in Heme Synthesis (6)*
12:00 AM | November 30, -0001Author: Adeleke
GAP UP Here: Glycine + Succinyl CoA -> Aminolevulinic Acid (ALA) -> Porphobilinogen -> Uroporphyrinogen-III -> Protoporphyrin -> HemeContinue reading
Archives
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What enzyme is deficient in Acute Intermittent Porphyria?
12:00 AM | November 30, -0001Author: Adeleke
Uroporphyrinogen SynthaseContinue reading
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Dx: Painful abdomen; Pink urine (Port-wine urine); Polyneuropathy; Psychological disturbances
12:00 AM | November 30, -0001Author: Adeleke
4 P = PorphyriaContinue reading
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Porphyria that also causes blistering of the skin from photosensitivity
12:00 AM | November 30, -0001Author: Adeleke
Porphyria Cutanea TardaContinue reading
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Dx: Patient is given a barbituate and begins projectile vomiting, confusion, abdominal pain, paranoia.
12:00 AM | November 30, -0001Author: Adeleke
Acute Intermittent PorphyriaContinue reading
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(3)* causes of Increased Indirect Bilirubin
12:00 AM | November 30, -0001Author: Adeleke
HCG: Hemolysis; Crigler-Najjar syndrome; Gilbert's syndromeContinue reading
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(2) conditions that increase Direct Bilirubin
12:00 AM | November 30, -0001Author: Adeleke
Hepatic damage Bile duct obstructionContinue reading
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What are the (2) required AA for Pyrimidine synthesis?
12:00 AM | November 30, -0001Author: Adeleke
Glutamatine Aspartic AcidContinue reading
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Blocking THF creation would lead to not being able to make what? What (3) drugs do this? What is the side effect of all of these drugs?
12:00 AM | November 30, -0001Author: Adeleke
Thymidine (dTMP) Drugs that block DHF reductase: METHotrexate (cancer); TriMETHoprim (PCP); PyriMETHamine (toxoplasmosis) Side effect: Bone marrow SuppressionContinue reading
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What are the (3)* important enzymes in the conversion of UMP to dTMP (in order)? Which Anti-cancer med targets each?
12:00 AM | November 30, -0001Author: Adeleke
Right Here The Funky Drugs Mingle: Ribonucleotide Reductase (Hydroxyurea) Thymidylate synthase (5-FU) DHF reductase (Methotrexate)Continue reading